ytcB [2017-05-17 11:12:48]

putative UDP-glucose epimerase

locus: BSU30870

pI: 8.87

mw: 34.76 kDa

protein length: 316 aa

gene length: 948 bp

function: unknown

product: putative UDP-glucose epimerase

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]

Gene

Coordinates: 3,157,008 → 3,157,958

The protein

Protein family

• sugar epimerase family (according to Swiss-Prot)

Structure

• [PDB|1SB8] (Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase, 34% identity) [Pubmed|15016816]

Expression and Regulation

Operons

• genes: [gene|59024C05AA0106719C81E45E3B060A6F710B2690|ytcA]-[gene|A51B5F9F86D2F7B690712B9EC181B1C07B312E02|ytcB]-[gene|6911DFB27F6A23F3775DAC5C289EFA163FBD1E56|ytcC]
  description: [Pubmed|22383849]

  sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|22383849,15699190,12480901], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

  regulatory mechanism

  • [protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|GerE]: repression, [Pubmed|26577401], in [regulon|19228BAD44E6DA3DE908DC390FDF628C18D94E65|GerE regulon]

  regulation

  • expressed late during sporulation in the mother cell ([protein|6FAD8804AA32B84819DDE57C0AF63F208FB9FFD1|SigKC], [SW|GerE]) [Pubmed|26577401,15699190,12480901]

Biological materials

Mutant

• MGNA-A279 (ytcB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/279 NBRP B. subtilis, Japan]

References

• 22383849,26577401,15016816